FOR IMMEDIATE RELEASE
REVIVICOR ANNOUNCES PURCHASE OF XENOTRANS LTD. ASSETS
BLACKSBURG,
Virginia: Revivicor Inc., a world-leading company in
the development of therapeutic products derived from pigs for use in humans
(xenotransplantation), announced today it has purchased essentially all of the
intellectual property and tangible assets of XenoTrans
Ltd. (XTL), an Australian company also focused on xenotransplantation
technology. As part of the agreement,
Revivicor has acquired, among other assets, all XTL intellectual property (IP)
and know-how relating to pig alpha-1,3 galactosyl transferase
(“GT”). Elimination or knockout of the
pig GT gene is a critical step for prevention of hyperacute
rejection of pig tissues when transplanted into humans. Revivicor was the first company to clone
pigs, and later, was the first company to generate GT negative pigs (“knockout”
pigs). XTL, a spinout company from the
Austin Research Institute (ARI), was the exclusive licensee of GT and other
xenotransplantation IP from ARI. ARI has
the first issued patents in the United States
and Australia
for the pig GT gene and its use for the development of GT knockout pigs. Revivicor, through this asset acquisition,
obtains exclusive rights to the ARI GT IP.
As part of this transaction, XTL shareholders will receive a minority
equity stake in Revivicor. Dr. Ian Mckenzie, one of the key inventors on the ARI GT patent and
the former CEO of XTL will assume a position on Revivicor’s
Scientific Advisory Board.
David Ayares, Revivicor’s Chief Executive Officer, stated, “The
acquisition of XTL assets, when combined with our IP and expertise in pig
cloning technology, positions Revivicor well for successful commercialization
of a variety of therapeutic products derived from pigs, including pancreatic
islet cells for treatment of diabetes, whole organs such as heart and kidneys,
and tissues for medical devices, while providing a solution for the inadequate
supply of equivalent human tissues.”
Revivicor has been collaborating
for the past three years with the University of
Pittsburgh Medical Center (the #1 transplant hospital in the world) on
pre-clinical testing of organs from GT knockout pigs in non-human
primates. In addition, the Company has
an ongoing collaboration with scientists at Children's Hospital (Pittsburgh), as part of an
effort funded by the Juvenile Diabetes Research Foundation (JDRF), for the
development of pig islet xenografts intended to cure
diabetes.
Revivicor was formed on
April 8, 2003, as a spinout of the U.S. division of PPL Therapeutics
Plc, with an investment group lead by the University of
Pittsburgh Medical Center. In addition
to its advanced programs in xenotransplantation, Revivicor is developing
technologies for treatment of infectious disease using human polyclonal
antibodies produced in genetically modified livestock. The polyclonal antibody platform is supported
in part from a contract with the U.S. Department of Defense (DARPA) for the
development of biological warfare countermeasures and by a grant from the
Advanced Technology Program (ATP), a division of the National Institute of
Standards and Technology (NIST).