Saving Lives
Through Xenotransplantation

An Unlimited Supply of Organs for Transplantation

Revivicor seeks to...

  • Alleviate Human Suffering
  • Heal Patients in Need
  • Restore Quality of Life

Revivicor's Vision

To provide organs from gene-edited pigs to overcome the critical shortage of human organs for transplant.

There is a major shortage of organs for heart and kidney transplant.

~600,000 patients in the US have end-stage renal disease
~600,000 patients in the US have end-stage cardiac disease
~105,000 people are waiting for transplants in the US
~25,000 kidney transplants each year in the US
~3,800 heart transplants each year in the US
~17 people die each day waiting for an organ

Data based on United Therapeutics internal market research, the Health Resources & Services Administration and UNOS.

Xenotransplantation is a key solution.
Pigs can provide a plentiful and accessible supply of transplantable organs.

History

1996

Revivicor (successor to PPL Therapeutics) collaborated with the Roslin Institute to establish the world’s first cloned mammal

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World’s first cloned mammal

2000

Revivicor (successor of PPL Therapeutics) produced the world’s first cloned pigs

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World’s first pigs cloned

2001

Revivicor (successor to PPL Therapeutics) established the world’s first alpha-gal knockout pigs, the GalSafe™ lineage progenitors. The GalSafe™ line has one gene inactivated and this line is free of the epitope galactose alpha-1-3 galactose (alpha-gal)

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GalSafe™ Illustration

2003

Revivicor formed as a spin-out from PPL Therapeutics

Revivicor Logo

2011

Revivicor acquired by United Therapeutics Corporation to create an unlimited supply of manufactured organs for transplantation

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United Therapeutics Corporation Logo

2020

Revivicor received a first-of-its-kind approval from the FDA for use of the GalSafe™ pig as a source of food for human consumption, and as a source of human therapeutics

Health and Safety Data FDA News Release
GalSafe™ FDA Approved Illustration

2021

Revivicor's UKidney™ from a pig was transplanted into the body of a recently deceased human maintained on artificial support UKidney™ is a development-stage product not approved for sale in any jurisdiction

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UKidney™ Logo

2022

A UHeart™ from a Revivicor pig was used clinically and established a new record for longest surviving recipient of a xenotransplantation productUHeart™ is a development-stage product not approved for sale in any jurisdiction

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UHeart™ Logo