Publications

Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review

Leigh Peterson, Magdi Yacoub, David Ayares, Kazuhiko Yamada, Daniel Eisenson, Bartley P. Griffith, Muhammad Mohiuddin, Will Eyestone, J. Craig Venter, Ryszard T. Smolenski, and Martine Rothblatt

Physiological Reviews First published:  22 March 2024

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Physiologic homeostasis after pig-to-human kidney xenotransplantation

Eric Judd, Vineeta Kumar, Paige M. Porrett, Kelly A. Hyndman, Douglas J. Anderson, Maggie E. Jones-Carr 2, Andrew Shunk, Daniel R. Epstein, Huma Fatima, Akemi Katsurada, Ryousuke Satou, L. Gabriel Navar, Jayme E. Locke

Kidney International Journal First published:  28 January 2024

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Normal Graft Function After Pig-to-Human Kidney Xenotransplant

Jayme E. Locke, Vineeta Kumar, Douglas Anderson Paige M. Porrett

JAMA Surgery First published:  16 August 2023

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Pig-to-human heart xenotransplantation in two recently deceased human recipients

Nader Moazami, Jeffrey M. Stern, Karen Khalil, Jacqueline I. Kim, Navneet Narula, Massimo Mangiola 2, Elaina P. Weldon, Larisa Kagermazova, Les James, Nikki Lawson, Greta L. Piper, Philip M. Sommer, Alex Reyentovich, Daniel Bamira, Tajinderpal Saraon, Bernard S. Kadosh, Michael DiVita, Randal I. Goldberg, Syed T. Hussain, Justin Chan, Jennie Ngai, Thomas Jan, Nicole M. Ali, Vasishta S. Tatapudi, Dorry L. Segev, Shivani Bisen, Ian S. Jaffe, Benjamin Piegari, Haley Kowalski, Maria Kokkinaki, Jeffrey Monahan, Lori Sorrells, Lars Burdorf, Jef D. Boeke, Harvey Pass, Chandra Goparaju, Brendan Keating, David Ayares, Marc Lorber, Adam Griesemer, Sapna A. Mehta, Deane E. Smith, Robert A. Montgomery

Nature Medicine First published:  24 July 2023

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Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report

Prof Muhammad M Mohiuddin, MBBS., Avneesh K Singh, Ph.D., Linda Scobie, Ph.D., Corbin E Goerlich, M.D., Alison Grazioli, M.D., Kapil Saharia, M.D., et al.

The Lancet First published:  29 June 2023

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Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

Bartley P. Griffith, M.D., Corbin E. Goerlich, M.D., Ph.D., Avneesh K. Singh, Ph.D., Martine Rothblatt, Ph.D., Christine L. Lau, M.D., Aakash Shah, M.D., Marc Lorber, M.D., Alison Grazioli, M.D., Kapil K. Saharia, M.D., Susie N. Hong, M.D., Susan M. Joseph, M.D., David Ayares, Ph.D., et al.

The New England Journal of Medicine First published:  22 June 2022

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Results of Two Cases of Pig-to-Human Kidney Xenotransplantation

Robert A. Montgomery, M.D., D.Phil., Jeffrey M. Stern, M.D., Bonnie E. Lonze, M.D., Ph.D., Vasishta S. Tatapudi, M.D., Massimo Mangiola, Ph.D., Ming Wu, M.D., Elaina Weldon, M.S.N., A.C.N.P.-B.C., Nikki Lawson, R.N., Cecilia Deterville, M.S., Rebecca A. Dieter, Pharm.D., B.C.P.S., Brigitte Sullivan, M.B.A., Gabriella Boulton, B.A., Brendan Parent, J.D., Greta Piper, M.D., Philip Sommer, M.D., Samantha Cawthon, B.S., Erin Duggan, M.D., David Ayares, Ph.D., Amy Dandro, M.S., Ana Fazio-Kroll, Ph.D., Maria Kokkinaki, Ph.D., Lars Burdorf, M.D., Ph.D., Marc Lorber, M.D., Jef D. Boeke, Ph.D., Harvey Pass, M.D., Brendan Keating, Ph.D., Adam Griesemer, M.D., Nicole M. Ali, M.D., Sapna A. Mehta, M.D., and Zoe A. Stewart, M.D., Ph.D.

The New England Journal of Medicine First published:  19 May 2022

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Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

Muhammad M. Mohiuddin, Corbin E. Goerlich, Avneesh K. Singh, Tianshu Zhang, Ivan Tatarov, Billeta Lewis, Faith Sentz, Alena Hershfeld, Gheorghe Braileanu, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Jamie Hittman, Adnan Bhutta, Ali Tabatabai, Anuj Gupta, Todd Vaught, Lori Sorrells, Kasinath Kuravi, Amy Dandro, Will Eyestone, David J. Kaczorowski, David Ayares, Bartley P. Griffith

Xenotransplantation First published:  31 March 2022

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First clinical-grade porcine kidney xenotransplant using a human decedent model

Paige M. Porrett, Babak J. Orandi, Vineeta Kumar, Julie Houp, Douglas Anderson, A. Cozette Killian, Vera Hauptfeld-Dolejsek, Dominique E. Martin, Sara Macedon, Natalie Budd, Katherine L. Stegner, Amy Dandro, Maria Kokkinaki, Kasinath V. Kuravi, Rhiannon D. Reed, Huma Fatima, John T. Killian Jr., Gavin Baker, Jackson Perry, Emma D. Wright, Matthew D. Cheung, Elise N. Erman, Karl Kraebber, Tracy Gamblin, Linda Guy, James F. George, David Ayares, Jayme E. Locke

American Journal of Transplantation First published:  20 January 2022

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Pig-to-baboon lung xenotransplantation: Extended survival with targeted genetic modifications and pharmacologic treatments

Lars Burdorf, Christopher T. Laird, Donald G. Harris, Margaret R. Connolly, Zahra Habibabady, Emily Redding, Natalie A. O'Neill, Arielle Cimeno, Dawn Parsell, Carol Phelps, David Ayares

American Journal of Transplantation First published:  23 August 2021

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The genetically engineered heart as a bridge to allotransplantation in infants just around the corner?

David C Cleveland, Abhijit Jagdale, Waldemar F Carlo, Hayato Iwase, Jack Crawford, Gregory P Walcott, Robert J Dabal, Robert A Sorabella, Leslie Rhodes, Joey Timpa, Silvio Litovsky, Carlisle O'Meara, Luz A Padilla, Jeremy Foote, David Mauchley, Mohamed Bikhet, David Ayares, Takayuki Yamamoto, Hidetaka Hara, David Kc Cooper

The Society of Thoracic Surgeons First published:  04 June 2021

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Allergic response to medical products in patients with alpha-gal syndrome

Kuravi KV, Sorrells LT, Nellis JR, Rahman F, Walters AH, Matheny RG, Choudhary SK, Ayares DL, Commins SP, Bianchi JR, Turek JW.J

Thorac Cardiovasc Surg. First published:  09 April 2021

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Biomanufacturing of axon-based tissue engineered nerve grafts using porcine GalSafe neurons

Katiyar KS, Burrell JC, Laimo FA, Browne KD, Bianchi JR, Walters A, Ayares DL, Smith DH, Ali ZS, Ledebur HC, Cullen DK.

Tissue Eng Part A. First published:  09 April 2021

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Pig kidney xenotransplantation: Progress toward clinical trials

Cooper DKC, Hara H, Iwase H, Yamamoto T, Wang ZY, Jagdale A, Bikhet MH, Nguyen HQ, Foote JB, Paris WD, Ayares D, Kumar V, Anderson DJ, Locke JE, Eckhoff DE.

Clin Transplant. First published:  01 November 2020

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Growth hormone receptor knockout: Relevance to xenotransplantation

Hayato Iwase, Suyapa Ball, Kent Adams, Will Eyestone, Anneke Walters, David K. C. Cooper

Xenotransplantation First published:  14 October 2020

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Heterotopic porcine cardiac xenotransplantation in the intra-abdominal position in a non-human primate model

Goerlich, C., DiChiacchio, L., Zhang, T., Singh, A., Lewis, B., Tatarov, I., Hershfeld, A., Sentz, F., Ayares, D., Corcoran, P., Horvath, K., Mohiuddin, M.

Nature Scientific Reports. First published:  01 July 2020

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Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

Cooper DKC, Hara H, Iwase H, Yamamoto T, Li Q, Ezzelarab M, Federzoni E, Dandro A, Ayares D.

Xenotransplantation First published:  15 April 2019

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